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The activity of luciferase was no longer reduced (Figure 5G)

Maternal consumption of high-fat diet in mice alters hypothalamic Notch pathway, NPY cell population and food intake in offspring

There are no validated or widely accepted clinical diagnostic criteria for DS-associated dementia

As in T2D, APD-induced increases in circulating insulin are hypothesized to desensitize insulin-sensitive peripheral targets (e.g., liver, skeletal muscle, adipose tissue) over time, resulting in insulin resistance and weight gain 3,4,15