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For instance, astrocytic LDHA downregulation in Alzheimers disease may not only impair energy supply but also directly suppress synaptic plasticity genes via epigenetic modifications (e.g., H3K18 lactylation)(Yao et al., 2023)

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Zhang X, Liu P, Zhang C et al (2017) Positive regulation of Interleukin-1 bioactivity by physiological ROS-mediated cysteine S-Glutathionylation

This dual effect results in reduced adiposity and improved fat utilization for energy, which has led researchers to explore its role as a metabolic regulator rather than a simple weight loss agent