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For some patients, the brain fog completely resolved, allowing them to resume normal daily activities and full workloads, prompting researchers to pursue larger, placebo-controlled randomized clinical trials to formalize this protocol

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In type 2 diabetes management, for example, NICE guideline NG28 supports the use of multiple agents with complementary mechanisms when monotherapy is insufficient

NORSE and FIRES are defined below: Epilepsia partials continua (EPC) is defined & discussed here: NORSE NORSE definitions New-onset Refractory Status Epilepticus (NORSE) : New-onset seizure with refractory status epilepticus (i.e., refractory to two medications such as benzodiazepine plus levetiracetam)