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Cu+ binds to the fatty acylated pyruvate dehydrogenase complex, inducing abnormal oligomerization and inactivation of the enzyme, which prevents pyruvate conversion to acetyl-CoA and disrupts metabolic flow via the tricarboxylic acid cycle (173,183)

Peptide- and non-peptide-containing unmyelinated primary sensory afferents: the parallel processing of nociceptive information

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Almost all melanomas show an initial radial growth phase followed by a subsequent vertical growth phase

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