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Peer review Peer review information Nature Reviews Neurology thanks Mu-Hong Chen, and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

10.1002/mco2.70268 MedComm 45 LotfiA.SoleimaniM.GhasemiN

While the prevalence of sporadic CAA increases with age, instances of early-onset CAA have been reported particularly in the context of prior neurosurgical interventions

Dual-luciferase reporter assay The mouse Hnf4a promoter sequences were inserted into the NheI/HindIII site of the luciferase pGL3-Basic vector (Promega, USA)