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10.1016/j.ctim.2021.102769 18 LiuH.WeiP.KapplerJ

10.4161/cc.8.20.9701 55 HegiM.DiserensA.HamouM

Most compounds that target tumor metabolism (methotrexate, 5-fluorouracil) fail to distinguish between tumor tissue and rapidly differentiating epithelial tissue (skin, bone marrow), 4,322 whereas therapies targeting the specific amino acid dependence of tumor cells are cell-selective, such as leukemic blasts that are selectively dependent on Asn, the use of bacterial-derived ASNase in pediatric ALL has significantly improved the cure rate