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IFN - , which plays a key role in vitiligo pathogenesis, feedback through crosstalk to promote CD8 + T cell recruitment to the skin (Rashighi et al., 2014)

The enzymatic antioxidant defense system comprises superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) (31)

While this drug is generally well tolerated, it can cause vomiting and lethargy in a subset of cats

However, the use of plasmid-mediated siRNAs has limitations of rapid enzymatic degradation or unwarranted hyper-stimulated immune reaction and the most serious drawback was the random siRNA insertion into chromosomes [123]