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Moreover, surgical treatment involves deep brain stimulation (DBS) and lesioning surgery, out of which the former could be effective for patients of PD in the advanced stage who no longer respond adequately to the medicines

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Another study has also demonstrated that AGEs-RAGE pathways can contribute to the development of PD, with their mechanism of action associated with inflammatory response ( 4.4 Analysis of molecular docking and molecular dynamics simulation results The molecular docking results of this study suggest that IL-6 and Adenosine have the strongest binding affinity, with a binding energy of 7.6 kcalmol 1

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In fact, one of the key changes in physiology associated with longevity is an increased acetylation of mitochondrial proteins [9]