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221 Upon exposure to cellular stress, decreased MDM2 levels and increased p53 levels induce a consistent interaction between p53 and GSK3, possibly promoting tau hyperphosphorylation

Although there have been some recent mechanism-related studies, relevant clinical research is still lacking at present

Wolfson ML, Aisemberg J, Correa F, Franchi AM (2017) Peripheral blood mononuclear cells infiltration downregulates decidual FAAH activity in an LPS-induced embryo resorption model: NO modulates decidual FAAH activity

Bottom line from the research: creatine won't directly cause fat loss, but it's a powerful tool for improving body composition when combined with proper training and nutrition

2c,d, Extended Data Fig