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In mice, CLN3 was shown to be highly abundant in neuronal cells, localizing to axonal extensions and synaptosomes, suggesting a role in synapses regulation [9]

Each additional receptor target adds complexity to the side effect profile, the dose-response relationship, and the long-term safety considerations

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Immediate-early proteins (IE1 and IE2) activate viral gene expression and modulate host immunity

In the transformation of hemorrhage after cerebral ischemia, iron overload significantly decreases oxidation metabolism, lactic acid generation, and brain pH value, further increasing iron release