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KLF4 also inhibits glycolysis under PS/LS compared to OS through glucokinase regulator protein (GCKR) transcription and AMPK-dependent GCKR phosphorylation, as demonstrated in a high-level voluntary running mouse model of exercise training [204]

eNAMPT rapidly increased IL-6 protein secretion, which activated STAT3-induced prosurvival signals upon autocrine/paracrine binding to the IL-6 receptor

EGFR pathway ROS promote ligand-independent initiation of EGFR in several ways, involving EGFR phosphorylation at the Tyr845 residue, 280 and/or inhibition of EGFR inhibitory PTPs (at Cys124 and Cys71) and/or Cys797 oxidation of EGFR

Moreover, glutamate is the only amino acid that can stimulate afferent gastric vagal nerves (59)

Inactivation or loss of NF1 led to hyperactivation of RAS, MAPK and AKT, and increased proliferation and survival of NSCs and facilitated engraftment and survival of NSCs in vivo (99)