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Multivariate analysis revealed some predictive factors of 90 th -day poor clinical outcomes, including older age (OR 1.12, p = 0.007), male sex (OR 14.56, p = 0.023), predominant hemisphere lesion (OR12.30, p = 0.026), increased NIHSS of 2 points (OR 34.47, p = 0.006), and large artery atherosclerosis classification (OR 13.08, p = 0.016)

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In contrast, DEDTC is a very strong acid ( pK a = 3.37), which would lead to a greater concentration of the active nucleophilic species at physiological pH (faster reaction rate), but would also yield less stable, more reversible adducts (thermodynamically unfavorable)

Zhang Z Cell or Cell Membrane-Based Drug Delivery Systems

30 There is conflicting data in the literature regarding the use of oral zinc supplementation in the treatment of acne