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Sixteen novel mutations in the Cu/Zn superoxide dismutase gene in amyotrophic lateral sclerosis: a decade of discoveries, defects and disputes

Loss of dopaminergic neurons involves neuroinflammatory mechanism and oxidative stress through the elevated level of inducible nitric oxide synthase (iNOS) followed by activated astrogliosis, T-cell infiltration, and microglia that leads to the accumulation of NO and O 2 free radicals

ROS production during the aging process has been associated with p38 MAPK, JNK, and ERK activities (Zhang et al., 2015)

Monti D, Sotgia F, Whitaker-Menezes D, Tuluc M, Birbe R, Berger A, Lazar M, Cotzia P, Draganova-Tacheva R, Lin Z, Domingo-Vidal M, Newberg A, Lisanti MP, Martinez-Outschoorn U

Shome, A., Sarkhel, R., Apoorva, S., Nair, S