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Interestingly, a fraction of OPCs in the adult brain remain at the stage of immature progenitors and can respond to neuronal activity by proliferation and differentiation (Gibson et al., 2014), to adapt myelination to the needs of active networks

Despite limited investigation of sex and other biological variables potentially influencing ketamines opioid-dependent therapeutic efficacy, preliminary preclinical work suggests subanesthetic ketamine evokes opioid-mediated behavioral and neurophysiological effects in male but not female rats 46

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[133] showed that, compared to a healthy population, fecal samples from PD patients had a significant reduction in Prevotellaceae (77.6%) alongside an increase in Enterobacteriaceae