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In hepatocytes, autophagy promotes lipid clearance (lipophagy) and reduces steatosis

And so you have an enzyme in your digestive system that does that

After administration of M2-EVs into the joint of a CIA mouse model, the STMs polarization was significantly shifted from M1 to M2 phenotype in decreased joint swelling, arthritic index score and synovial inflammation, with corresponding reductions in bone erosion and articular cartilage damage (Kim et al., 2022a)