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These results also suggested that the inhibition of COX-2 by etoricoxib could upregulate the Nrf2 signaling pathway to ameliorate erastin-induced ferroptosis (erastin+DMSO vs

Engstrom K

PLoS ONE 19 (3), e0297155 (2024)

Originating from the abnormal physiological state that causes epilepsy, breakage of the BBB loop leads to changes in permeability that can ultimately lead to abnormal entry of substances from small molecules to intact cells (17, 65), which is in turn evidence of microvascular dysfunction in epilepsy (66, 67)