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In DBA/2 J mice, increased levels of mitochondria with altered morphology and diminished capacity for oxidative metabolism, together with decreased LAMP1, despite increased numbers of autophagosomes, led to the belief that these mice had impaired mitophagy (Coughlin et al., 2015)

It was demonstrated that cysteine S -conjugate -lyase highly expressed in the kidney was responsible for the observed nephrotoxicity (Zhang and Hanigan, 2003

The neuroprotective effect of DMSO observed in this study agrees with other studies reported by (Torre et al., 1973) who first reported the potential therapeutic effect of DMSO in central nervous system injury

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The Effect of Omega-3 Fatty Acids on Insulin Resistance