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extensive tissue breakdown (such as with severe burns)

On the other hand, a significant increase in TDO expression has been found in preeclampsia, but since inflammatory response is involved in the pathogenesis of preeclampsia, it can be hypothesized that upregulation of TDO cannot fully compensate for the decrease in IDO in this regard

HIF-1 is inactivated in normoxia by prolyl hydroxylase enzymes (PHD 1-3) using oxygen as a substrate

0.1% (v/v) formic acid and 2% (v/v) acetonitrile in water was used to wash the trap cartridge, followed by the separation of the concentrated peptides using a SCIEX capillary reverse-phase column (ChromeXP, 3C18-CL-120, 3 m, 120 and 0.3 150 mm)

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