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In this review, we describe the main features of cardiac energy metabolism in the healthy heart and its abnormalities in HF with emphasis on the role of B vitamins

They also modulate inflammatory and antimicrobial processes [4,5], which extend to the prevention of pathologies related to metabolic syndrome, cardiovascular diseases, tumors [6,7,8,9] and, as will be seen in this review, some diseases of the nervous system as well

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In addition, none had engaged in shift work that included night shifts or had traveled with more than 6 h of jet lag in the 3 months prior to the experiment

Consistently, increased insulin signaling in key insulin-sensitive tissues, as indicated by elevated phosphorylation of Akt after the mice were challenged with insulin, was observed in aged Mmp14 +/ mice (Fig