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This is not limited to just bile

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After feeding all branching pathways, the excess of glycolytic flux is converted to lactate to preserve a sufficient pool of NAD+ for glycolysis and also to avoid the tricarboxylic acid (TCA) cycle inhibition due to excess NADH

Zhou, Synthesis of lipophilic vitamin C and evaluation of its antioxidant performance in sunflower seed oil frying

This so-called "sulfate factor" was subsequently isolated from the rat serum and named "somatomedin." Concurrently, an independent study explored the components responsible for producing insulin-like activity