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Results L-carnitine increased the gastrocnemius muscle (GM) weight in the CT26-bearing cachexia mouse model and the cross-sectional fiber area of the GM and myotube diameters of C2C12 cells treated with TNF-

83 Furthermore, R1881 (synthetic androgen) increased the expression and activity of CPTI, the rate-limiting enzyme in the process of mitochondrial FAO, through AR-mediated pathway, leading to increased production of ROS associated with prostate cell proliferation and mutagenesis

3.3 Trimethylamine-N-oxide is a marker of renal impairment and a renal toxin Since the kidney is the primary site of TMAO elimination from the body ( 2 ) and with poor prognosis in patients with CKD (Tang et al., 2015b)

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FIGURE 2 FIGURE 3 FIGURE 4 Validation of selected metabolite biomarkers through selected reaction monitoring Figure 5 depicts the quantification results of acetylcarnitine selected as the final biomarker candidate in the validation set