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A study involving azoxymethane (AOM)-induced CRC mice, as well as Caco2 and SW480 cell lines, demonstrated that the combined treatment of chemotherapy drugs such as 5-fluorouracil (5-FU) or celecoxib (Cel) at varying concentrations, alongside the natural compound anthocyanin, effectively inhibited cell proliferation and reduced tumor numbers in AOM-induced CRC mice

Two consensus animals were excluded from this analysis, as they were found dead after multiple hours and rigor mortis had already set in, rendering the value of tissue analysis low

Neuronal activity DNA methylation appears to have a dynamic nature in neurons, as it can be regulated by physiological or environmental (drugs, injuries, electroconvulsive stimulation, exercise) factors, which ultimately influence neuronal activity and cognitive functions