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10.1016/j.ejphar.2022.175213 2 AhmadN.AhmadR.AlrasheedR

Quantitative proteomic analysis of castor ( Ricinus communis L) seeds during early imbibition provided novel insights into cold stress response

fumigatus also has specific enzymes for detoxification of ROS produced by macrophages and neutrophils, such as five catalases (catA, cat1/catB, catC, catE, and cat2)48,208,215 and four superoxide dismutases (SODs): a cytoplasmic Cu/ZnSOD (Sod1), a mitochondrial MnSOD (Sod2), a cytoplasmic MnSOD (Sod3), and Sod4 displaying a MnSOD C-terminal domain.87,113,147 Deletion of catA, a conidial catalase, resulted in increased susceptibility of conidia to H2O2in vitro, but the virulence of the mutant strain did not change in a murine model.215

This article shows that antioxidants promote cancer metastasis in vivo, triggering further debates on the controversial roles of antioxidants in cancer treatment