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Nat Genet (2010) 42(7):5705

Chemical exfoliation: Gently exfoliating the skin daily with a chemical exfoliant can help slough off keratin plugs that are responsible for forming KP

In future studies, further analyses, including assessing the activities of antioxidant enzymes such as SOD, catalase and glutathione peroxidase, may provide more comprehensive data on the effects of uric acid, and these additional markers will help to elucidate cellular antioxidant defense mechanisms and their response to uric acid-induced oxidative stress

However, when glutamate accumulates outside the synapse, it activates extrasynaptic NMDA receptors, which suppress CREB signaling and initiate neurotoxic cascades, in contrast to synaptic NMDA receptors that promote survival and plasticity (128, 129), This receptor-location-dependent signaling shift contributes to dendritic atrophy and functional decline observed in stress-related disorders such as depression

The Nrf2 pathway, a major antioxidative mechanism in astrocytes, also becomes dysregulated during neurodegeneration