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Nevertheless, there are limitations to our study and open questions remain

Mechanistically, lipopolysaccharide (LPS)-induced lung injury was less severe and had less neutrophil infiltration and endothelial exudation in sphingosine kinase (SPK)1-/- mice compared to wild type (WT) mice, with decreased numbers of inflammatory cells in theBAL

Amino acid sidechains of Tyr phosphoacceptors, residues at substrate priming positions and indicated complementary residues in kinase domain are shown in ball-and-stick representation

Jwko E, Gromisz W, Sadowski J, Cieliski I, Kotowska J

Moreover, excessive fission disrupts mitochondrial membrane potential, causes mitochondrial damage, and impairs both cellular energy metabolism and iron homeostasis, further sensitizing cells to ferroptosis [56]