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In SCLC, radiotherapy administered concurrently with chemotherapy is considered the standard and preferred therapeutic approach, and a shorter time between the start of any treatment and end of radiation therapy was significantly associated with improved survival (NCCN 2014b)

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O.Reyes-GrajedaJ

Ultraviolet radiation causes oxidative damage to methionine and tryptophan residues, which compromises receptor binding affinity

In contrast to the well-characterized calcium-activated scramblase TMEM16F, XKR8 mediates lipid scrambling upon caspase-3-mediated cleavage at its carboxy-terminal recognition site during apoptosis, leading to the externalization of PS on the outer leaflet of plasma membrane (PM)