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In the following sections, we introduce three types of therapies that are based on circadian rhythm regulation: pharmacological modulators, chrononanomedicine, and nonpharmacological interventions

-Dioxygenases, two of which exist (in tobacco and Arabidopsis ) and are distinct from the lipoxygenases (and related structurally to mammalian COX enzymes), work in concert with caleosins, i.e., Ca 2+ binding proteins associated with lipid bodies, to generate various 2 R hydroperoxy fatty acids and then the hydroxide, e.g., 2hydroxy-linolenic acid (illustrated)

Treatment with curcumin enhanced the expression of collagen and FN (Sidhu et al., 1998)