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PMID: 34046850

The metabolism of the patient will determine the answer

Nature 2021, 599:136140

While the specific mechanisms underlying asthma have yet to be identified, there is accumulating evidence that oxidative stress from altered GSH/GSSG redox status may play an important role in the modulation and severity of the disorder

Rosiglitazone (RGL), a synthetic agonist of PPAR (a key factor in fatty acid oxidation), can inhibit the secretion of chemokines and the activation of nuclear factor-B (NF-B) in human renal proximal tubular cells (PTCs) by activating PPAR SUMOylation, thereby suppressing inflammation and improving RF [81]