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Kielian T, Esen N, Liu S, Phulwani NK, Syed MM, Phillips N et al (2007) Minocycline modulates neuroinflammation independently of its antimicrobial activity in Staphylococcus aureus-Induced brain abscess

Given that mutations in the hydrophobic interaction surfaces on the LSM14 LSM domain completely disrupt 4ET binding in vivo , we conclude that the middle and Cterminal 4ET regions bind to the LSM domain in a highly similar, and likely mutually exclusive manner

doi: 10.1515/rns.2011.028 Summary Keywords Alzheimers disease, Parkinsons disease, amyotrophic lateral sclerosis, neurodegenerative diseases, antioxidant biomarkers, bidirectional Mendelian randomization study Citation Zhang Q, Li Q, Zhao H, Shu M, Luo M, Li Y, Ding Y, Shi S, Cheng X and Niu Q (2023) Neurodegenerative disease and antioxidant biomarkers: A bidirectional Mendelian randomization study

[150] [151] [12] See also [edit] References [edit] 1 2 3 "Nobel Prize in Physiology or Medicine 2011" (Press release)

Intramuscular (IM) B12 injections using hydroxocobalamin, the preferred licensed form in the UK are recommended when: Oral supplementation has failed to correct a documented deficiency The patient has difficulty adhering to daily oral regimens Serum B12 levels remain persistently low despite adequate oral dosing There is clinical evidence of neurological or haematological complications In line with BNF guidance, the standard IM regimen for confirmed deficiency without neurological involvement is a loading course of 1 mg hydroxocobalamin on alternate days for two weeks , followed by maintenance of 1 mg every three months