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39 Other cases have been reported with severe PFIC in homozygous ABCB4 mutations in children born to consanguineous parents

In addition, previous foundational studies, along with more recent work, have shown that DNA repair enzymes (such as mutT homologs) can maintain genomic stability by preventing the incorporation of oxidatively damaged nucleotides into DNA, offering a novel perspective for treating autoimmune diseases by targeting genomic instability (100,112)

Additionally, HNE-modified proteins are enriched within LBs, and HNE itself has been detected in the cerebrospinal fluid (CSF) of PD patients (Castellani et al., 2002

10.1074/jbc.M809687200

It should be emphasized that the abundance of bifidobacteria directly impacts the integrity of the intestinal barrier