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Some studies have shown that metformin can reduce the absorption of vitamin B12 in 30% of people with type 2 diabetes (Vitamin B12 deficiency in metformin-treated type-2 diabetes patients, prevalence and association with peripheral neuropathy)

Vitamin B12 injections have received a great deal of attention in recent years, driven partly by growing interest in fatigue, energy and general wellbeing

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Because many peptides are off-label or investigational, treatment should be medically supervised with lab testing and proper sourcing