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5-Amino-1-methylquinolinium (5-Amino-1MQ) is a selective small molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that plays a critical role in cellular metabolism and energy homeostasis

In laboratory testing, it did not inhibit related SAM-dependent methyltransferases or interfere with other enzymes in NAD+ salvage pathways

Pregnenolone: Pregnenolone is an endogenous steroid and precursor/metabolic intermediate that plays a key role in the production of other steroid hormones, including progesterone, DHEA, and estrogen

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