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Notably, alterations in the binding of AP-1 family members, such as FRA-2 and JUND, were closely linked to increased DNA methylation, suggesting that mutant HTT may disrupt normal transcriptional regulation (212)

A., Kavalakatt, J., Banerjee, S., De Alvares Goulart, R., Atanasov, A

After feeding mice a vitamin E-adequate and a vitamin E-deficient diet, the researchers found that the vitamin E-deficient mice showed a 90-fold decrease of -tocopherol in lung tissue, and a significant decrease of antioxidants and increased inflammatory response (182)

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