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Under normal conditions, AsA is available mostly in reduced form (Khan et al., 2011)

1991 Mar;53(3):695-7

A study on sumatriptan found higher posterior deposition for powder, but similar nasopharyngeal clearance rates for both forms [38]

A number of factors limit their use in therapeutics, including rapid degradation through nucleases, rapid clearance via renal filtration, and a lack of chemical diversity among others (90)