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Bcl-2 is the prototype of a family of genes and corresponding proteins that govern the permeability of the outer mitochondrial membrane and can be both pro-apoptotic (Bax, BAD, Bak, Bok and others) and anti-apoptotic (Bcl-2, Bcl-xL and Bcl-w, the main ones)

In order to compare the combined effect of metals and chelators in a comprehensive in vitro model, we engineered multidrug-resistant A431 cells overexpressing ABCB1/P-glycoprotein, ABCG2 or ABCC1/MRP1 (Fig S1, Fig S2, Fig S3)

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