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Earlier in vitro studies showed that these CE-rich particles effectively cholesterol load VSMCs (151,152)

Epidemiological findings indicate that DM is a strong and independent risk factor for cognitive impairment ( The link between diabetes and neurodegenerative disease has been well established, but the underlying mechanisms of pathological development remains unclear

Specifically, genomics helps to identify disease-related genes by analyzing massive data, promoting targeted drug development and personalized medicine (Schmidt et al., 2022)

Of these 10 studies, 1 was an open trial, which was considered of moderate quality, and the remaining studies were randomised controlled trials, all of high quality ( Table 2 )

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