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Dabrafenib monotherapy induced new RAI uptake in 60% (6/10) of BRAF V600E mutant RAIR-PTC patients, while reducing serum thyroglobulin levels [113]

Note the tears at the insertion point

*Correspondence: Giuseppe DAntona, [email protected] These authors have contributed equally to this work This article was submitted to Exercise Physiology, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Its also worth noting that this finding sits in tension with a much larger body of evidence, including observational studies suggesting benefit and randomized trials showing modest benefit or neutrality

The endocrine and metabolic adaptation observed in both models may be a strategy to increase life span through a slower cell growing/metabolism, a slower loss of physiologic reserve capacity, a shift of cellular metabolism from cell proliferation to repair activities and a decrease in accumulation of senescent cells