The molecular docking was performed based on the CB-Dock-2 tool ( CB-Dock-2 is a protein-ligand docking method that automatically identifies binding sites, calculates the center and size, customizes the docking box size based on the query ligands, and then performs molecular docking using AutoDock Vina [17]
If unchecked, in conditions such as neurological disorders, chronic inflammation causes enormous functional damage to neurons and glial cells, including astrocytes, microglia, and oligodendrocytes
The GI side effects are present but manageable
They observed that metformin could downregulate the expression of MMP-9/MMP-2 and mTOR while upregulating the expression of protein kinase B and adenosine monophosphate-activated protein kinase (AMPK), thereby inhibiting ovarian granulosa cells dysfunction and promoting their recovery of follicle function ( in vitro studies utilizing human granulosa tumor-derived cell models demonstrates that metformin intervention effectively downregulates multiple components of the LPS-activated inflammatory cascade, including LPS-induced miR-670-3p , NOX2 , NLRP3 , ASC , and GSDMD-N , as well as reducing cellular caspase-1 activity, ROS production, and secretion of inflammatory factors
Relevant studies indicate that dehydroascorbate stimulates pentose phosphate pathway enzymes, increases intracellular glutathione levels, and inhibits hydrogen peroxide-induced mitochondrial transmembrane potential dissipation and cell death, highlighting its antioxidant role ( Conclusion Taoling Yuyang Decoction can improve DSS-induced colitis in mice through multiple mechanisms, including reducing oxidative stress, inhibiting inflammatory response, repairing intestinal barrier function, remodeling intestinal flora homeostasis, restoring SCFAs metabolism, and regulating fecal metabolic pathway
