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SVCT2 overexpression and ascorbic acid uptake increase cortical neuron differentiation, which is dependent on vitamin C recycling between neurons and astrocytes

PGD 2 production in DMD is involved in the expansion of muscular necrosis caused by muscular inflammation based on the observation that the administration of HPGDS inhibitors, including HQL79, TAS204, and TAS205, ameliorates muscular atrophy by decreasing urinary tetranor-PGDM concentrations in animal models 10,19,20,21 and in patients with DMD 22,23

Puliyasseri, R., Haribabu, J., Ramirez-Tagle, R