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Full receptor profile: High affinity (Ki 90% of H1 antihistamine receptors at peak serum levels, so its conceivable that peak sedating effects from quetiapine could occur in a relatively low dosing range (e.g., ~50-100 mg)

The glutamate produced during the glutamine metabolism is further converted into -ketoglutarate (-KG) through glutamate dehydrogenase 1 (GLUD1), transaminases such as glutamate-oxaloacetate transaminase (GOT), glutamate-pyruvate transaminase (GPT), and phosphoserine transaminase (PSAT) and subsequently participates in the TCA cycle

Peptides (2009) 30:9958

History First synthesized in the early 1990s by researchers investigating cytoprotective proteins found in gastric juice

The bidirectional interactions between thyroid function and the gut microbiota constitute the emerging concept of the gutthyroid axis, providing a novel framework for understanding the disease