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F.TakagiK.ShiomiK.MoriM.OmuraS.et al

A key observation is the disruption of cellular homeostasis, often coinciding with disease progression

8,9 Furthermore, smokers inhale 1 g of iron per 25 cigarettes and the smoke itself releases iron from ferritin, giving the lung surface fluid ample iron to generate the toxic hydroxyl radical through the Haber-Weiss and Fenton reactions