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Altogether, these data suggest that the ability of AML cells to prevent lipid peroxides accumulation by increasing their cystine uptake to support GSH after exposure to APR-246 is a key determinant of the sensitivity to this compound

[DOI] [PubMed] [Google Scholar] 101.Amelio P., Portevin D., Hella J., Reither K., Kamwela L., Lweno O., Tumbo A., Geoffrey L., Ohmiti K., Ding S., et al

It plays a crucial role in mediating UA reabsorption, a process in which approximately 90% of uric acid is typically reabsorbed following glomerular filtration

doi: 10.1016/0022-4731(79)90329-7

10.1073/pnas.0808517105 Proc Natl Acad Sci U S A