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Watermelon juice treated mice also showed a significant increase in superoxide dismutase activity in the tissues of the lung, brain, and liver [42]

These functions include promoting nerve growth factor expression, regulating myelin formation, and maintaining neuronal homeostasis (111)

However, the conclusions should be interpreted with caution due to considerable heterogeneity across studies, limited sample size, variations in curcumin formulations and dosages, and potential publication bias

Consistent with activation of the ISR, upregulation of P21, an effector of cell cycle arrest, was observed in organoids treated with the highest dose of DTG, which was ameliorated by the co-application of an ISR inhibitor, ISRIB