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In FRET, dipole-dipole coupling leads to the transfer of energy from an excited donor fluorophore to a neighboring acceptor fluorophore

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This observation is also supported by functional MRI (fMRI) studies showing that patients with early-stage mild cognitive impairment (MCI) display an hyperactivation of medial temporal lobe and hippocampal circuits during memory tasks, possibly reflecting inefficient compensatory activity 157,158,159,160,161,162,163 which has also been referred to as excessive and maladaptive synaptic plasticity