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The disease affects approximately 10% of the global population, with prevalence varying across regions due to differences in age, demographics, socioeconomic status, and access to healthcare (Rovin et al., 2024) and studies have consistently demonstrated a rising prevalence in both developed and developing countries

doi: 10.1053/j.gastro.2016.11.010 144 MaoXLarsenSBZachariassenLSFBrunseAAdambergSMejiaJLCet al

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The closest FDA-approved IGF-1 product is mecasermin (Increlex) , native recombinant human IGF-1, approved only for the long-term treatment of growth failure in pediatric patients with severe primary IGF-1 deficiency or GH gene deletion with neutralizing antibodies

c-Met antibody LY2875358 (LA480) shows differential antitumor effects in non-small cell lung cancer