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Oxidative stress occurs when the body is no longer able to 'mop up' excess free radicals, pro-oxidant molecules that 'rust' our cells and make them age faster

BLOOD SAMPLING, APOLIPOPROTEIN E GENOTYPING, MEASUREMENT OF PLASMA HOMOCYSTEINE CONCENTRATIONS, AND FATTY ACID ANALYSIS Blood was obtained in 0.1% EDTA at the 20th examination

Thus, the commensal microbiota can weaken the intestinal barrier through postnatal control of Hh signaling associated with TLR2-induced decreasing of NRP1 (Pontarollo et al., 2023)