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Description

Gastrointestinal exposure to silica nanoparticles induced Alzheimers disease-like neurotoxicity in mice relying on gut microbiota and modulation through TLR4/NF-B and HDAC

By doing so, IF modulates mitochondrial bioenergetics and oxidative stress response pathways in the brain, promoting neuronal survival and cognitive function during aging and neurodegeneration

[DOI] [PMC free article] [PubMed] [Google Scholar] Garway-Heath DF, Crabb DP, Bunce C, Lascaratos G, Amalfitano F, Anand N, Azuara-Blanco A, Bourne RR, Broadway DC, Cunliffe IA, Diamond JP, Fraser SG, Ho TA, Martin KR, McNaught AI, Negi A, Patel K, Russell RA, Shah A, Spry PG, Suzuki K, White ET, Wormald RP, Xing W, Zeyen TG, 2015