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This results in systemic signaling effects that extend beyond adipose tissue, making these compounds more suitable for studying integrated endocrine regulation rather than isolated metabolic pathways

It is more likely to occur in those patients receiving too much of the medicine but can occur with small doses as well

This is a concern that applies to all significant weight loss interventions, not just tirzepatide, but it becomes more relevant as the magnitude of weight loss increases

All of this is causing great pain to people who suffer from pernicious anemia or another type of gastric B12 malabsorption

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