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Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon

That antigen should strongly expressed on cancer cells but minimally present on normal cells

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Glucose deprivation together with glycolysis inhibition (using 2-deoxy-glucose, 2-DG) resulted in the inhibition of NET formation (compared to untreated PMA-stimulated neutrophils), while the addition of glucose alone maintained NET formation in the same conditions (Rodrguez-Espinosa et al., 2015) (Table 2)

49 This hypothesis led to the testing of the broad anti-fibrotic pirfenidone, which has proven efficacy for idiopathic pulmonary fibrosis, in Phase 2 trials in NF1 patients with advanced pNF but, unfortunately, no benefit of pirfenidone was reported 50 (NCT00076102)