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Antioxidants 11(8):1426

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Moreover, the limited bioavailability, poor water solubility, and chemical instability of resveratrol strongly restrict its in vivo biological effects [83]

A REMS is a drug safety program that the FDA can require for certain medications with serious safety concerns to help ensure the benefits of the medication outweigh its risks

*Correspondence: Bassem Sadek, [email protected] This article was submitted to Neuropharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers